Vemurafenib linked to therapeutic effect in various cancers
1. Participants with BRAF V600 mutation-positive small-cell lung cancer, Erdheim Chester Disease (ECD) and Langerhan’s-Cell Histiocytosis (LCH) demonstrated a modest but statistically significant...
View ArticleAdaptive ventilation for central sleep apnea linked to increased mortality in...
1. Patients with reduced ejection heart failure (HF) and central sleep apnea who received servo-assisted ventilation did not show a difference in the composite end point of death in comparison to...
View ArticleBivalirudin not linked to adverse cardiovascular events: The MATRIX program
1. Acute coronary syndrome (ACS) patients requiring percutaneous coronary intervention (PCI) who received either heparin or bivalirudin were not significantly different in either the rates of major...
View ArticleTargeted autologous transfusion may aid advanced refractory multiple myeloma
1. A sustained decrease of up to 12 months in serum IgA measurements was demonstrated after administration of CTL019 transfusion in a patient with multiple myeloma (MM). 2. A sustained decrease of up...
View ArticleLetrozole linked to lower rate of multiple gestation and live birth vs...
1. The rate of multiple clinical pregnancy was significantly higher in patients treated with gonadotropin compared to treatment groups with clomiphene or letrozole. 2. The rate of multiple gestation...
View ArticleCardiac risk factors more prevalent in obese children
1. Greater severity of weight class in pediatric patients associated with higher risk ratios of cardiometabolic risk factors including systolic and diastolic blood pressure (BP), HbA1c and...
View ArticleAcetaminophen not associated with reduced duration of ICU hospitalization
1. Early use of acetaminophen in febrile ICU patients with suspected infection did not reduce the number of ICU-free or hospital-free days for a 28 day study period. 2. Compared to the placebo group,...
View ArticleInfrequent exposure to malarial parasites associated with increased infections
1. Reduction in maternal antimalarial IgG levels was associated with decreased prevalence of malaria over a 10-year period in pregnant women. 2. Decrease in the prevalence of malaria over 10-year...
View ArticleNeoplastic tapeworm cells may invade human tissue in immunocompromised hosts
1. Human disease that resembles cancer found to be from parasite-derived cancer cells of Hymenolepis nana. Evidence Rating: 4 (Below Average) Study Rundown: The most common tapeworm known to...
View ArticleNew data on prevalence and spectrum of germline mutations in pediatric cancer...
1. Significantly higher prevalence of germline mutations in cancer-predisposition syndrome genes identified in pediatric cancer patients compared with non-cancer adult patients. 2. New associations...
View ArticleLixisenatide ineffective in reducing cardiovascular events in diabetics: The...
1. Treatment with lixisenatide in type 2 diabetic (DM2) patients was shown to result in rates of coronary events similar to those of placebo. 2. Treatment with lixisenatide in DM2 patients offers mild...
View ArticleArtesunate-amodiaquine therapy linked to lower Ebola mortality
1. Artesunate-amodiaquine (AA) treated Ebola patients had a significantly lower risk of death than artemether-lumefantrine (AL) treated patients. 2. The effect reduced mortality associated with AA...
View ArticleHigher prevalence of malpractice claims associated with prior paid claims and...
1. According to data from the National Practioner Data Bank (NPDB), a small proportion (1%) of all physicians accounted for a relatively larger number (32%) of paid claims. 2. The risk of recurrence...
View ArticleAdjunctive dexamethasone in HIV-cryptococcal meningitis linked with increased...
1. Adjunctive dexamethasone for HIV-associated cryptococcal meningitis did not reduce mortality. 2. Adjunctive dexamethasone for HIV-associated cryptococcal meningitis was associated with more adverse...
View ArticleLower oxygen-saturation targets associated with greater morbidity and...
1. A significantly higher risk of death and disability was found in extremely premature infants receiving lower-target oxygen-saturation compared to high-target oxygen-saturation. Evidence Rating...
View ArticleAdjunctive TMP-SMX (Bactrim) associated with higher clinical cure rates for...
1. Adjunctive TMP-SMX therapy in patients with cutaneous abscesses resulted in a significantly higher clinical cure rates compared to placebo. 2. Adjunctive TMP-SMX therapy in patients with cutaneous...
View ArticleIncidence and severity of dengue in pediatric patients higher in Southeast...
1. The disease burden and severity of virologically confirmed dengue appeared to be higher in Asian countries compared to Latin American countries Evidence Rating Level: 2 (Good) Study Rundown:...
View ArticleEating fresh fruit decreased the risk of cardiovascular disease in Chinese...
1. Higher consumption of fresh fruit was independently associated with lower risk of cardiovascular disease (CVD) in Chinese adults. Evidence Rating Level: 2 (Good) Study Rundown: CVD represents a...
View ArticleRecombinant vesicular stomatitis virus Ebola vaccine demonstrates immunogenicity
1. Zaire ebolavirus-glycoprotein-specific antibody responses were detected in all participants receiving vaccination doses from 300,000 to 50 million plaque-forming units (PFU). 2. Fever was reported...
View ArticlePediatric asthma associated with abnormal patterns of lung function growth...
1. Childhood impairment of lung function and male sex significantly predicted abnormal lung-function patterns of growth and decline in adulthood. 2. Childhood persistent asthma and reduced lung...
View Article