Adjunctive dexamethasone in HIV-cryptococcal meningitis linked with increased morbidity and mortality: The CryptoDex study

1. Adjunctive dexamethasone for HIV-associated cryptococcal meningitis did not reduce mortality. 2. Adjunctive dexamethasone for HIV-associated cryptococcal meningitis was associated with more adverse events and disability compared to placebo. Evidence Rating Level: 1 (Excellent) Study Rundown: HIV-associated cryptococcal meningitis causes approximately 600,000 deaths each year. For certain CNS infections, such as bacterial meningitis, glucocorticoids as