New data on prevalence and spectrum of germline mutations in pediatric cancer patients

  1. Significantly higher prevalence of germline mutations in cancer-predisposition syndrome genes identified in pediatric cancer patients compared with non-cancer adult patients. 2. New associations between germline mutations identified for TP53, PMS2 and RET and Ewing’s sarcoma and APC and SDHB mutations with neuroblastoma. Evidence Rating: 2 (Good)     Study Rundown: The prevalence of