Rosuvastatin associated with reduction of cardiovascular disease in all...
1. Intermediate-risk cardiovascular patients on rosuvastatin demonstrated significantly lower risk of cardiovascular events compared to patients on placebo. 2. Intermediate-risk cardiovascular patients...
View ArticleTenofovir treatment associated with reduced perinatal transmission of...
1. Perinatal transmission of hepatitis B virus (HBV) was lower in mothers treated with tenofovir disoproxil fumarate (TDF) compared to controls. 2. No significant difference in rates of birth defects...
View ArticleRTS,SA/S01 anti-malarial vaccine efficacy wanes significantly over time
1. RTS,SA/S01 malaria vaccine had significantly higher efficacy rates compared to placebo within the first year of administration. 2. Over the course of seven years, RTS,SA/S01 malaria vaccine efficacy...
View ArticleExtending adjuvant letrozole treatment may reduce breast cancer recurrence:...
1. Extended-use adjuvant letrozole therapy was associated with significant reduction in breast cancer-free survival but not overall survival, compared to placebo. 2. Extended-use adjuvant letrozole...
View ArticleMicrobe-rich environment associated with lower rates of asthma
1. Dust extracts from Amish households were found to have higher concentrations of endotoxins and allergens compared to extracts from Hutterite households. 2. Children from Amish households have lower...
View ArticleObeticholic acid associated with improved PBC biomarker trends compared to...
1. Obeticholic acid therapy in patients with primary biliary cholangitis (PBC) associated with significantly greater decreases in alkaline phosphatase (ALP) and total bilirubin over 12 month period...
View ArticleCombination salmeterol-fluticasone therapy noninferior to fluticasone...
1. The rate of adverse asthma-related events was similar in patients with asthma treated with fixed-dosed salmeterol-fluticasone therapy compared to fluticasone monotherapy. 2. The mean percentage of...
View ArticleNo difference in mortality for intensive versus standard reduction in blood...
1. There were no significant differences in the proportion of death and disability in patients with intracranial hemorrhage with blood pressures maintained at 140-179 mmHg versus 110-139 mmHg. 2. There...
View ArticleAdjunctive azithromycin reduces risk of non-elective cesarean post-operative...
1. Women receiving azithromycin in addition to standard antibiotic prophylaxis for cesarean section (c-section) were 49% less likely to develop endometritis and postoperative wound infections compared...
View ArticleAdvent of mammography associated with increased detection of smaller breast...
1. After advent of mammography, detection rate of large tumors decreases while detection of smaller tumors increases. 2. The decreased rate of large tumor detection was a direct result of increased...
View ArticlePediatric screening for family hypercholesterolemia is feasible and efficacious
1. Presence of a familial hypercholesterolemia mutation without elevated total cholesterol levels is insufficient to make diagnosis of familial hypercholesterolemia. Evidence Rating Level: 3 (Average)...
View ArticleSemaglutide reduces cardiovascular risk in diabetics: The SUSTAIN-6 trial
1. The two-year risk of developing cardiovascular death, nonfatal myocardial infarction (MI) or stroke was approximately 25% less in patients taking semaglutide compared to placebo. 2. Two-year use of...
View ArticleMolecular markers associated with bone marrow clearance in AML and MDS
1. TP53 mutant status significantly associated with bone marrow blast clearance after treatment with decitabine in patients with acute myelogenous leukemia (AML) or myelodysplastic syndromes (MDS)....
View ArticleAdverse neurologic outcomes associated with maternal Zika virus infection
1. Infants born to symptomatic Zika-positive mothers demonstrated higher rates of fetal death, fetal growth restriction and central nervous system abnormalities. 2. Zika-positive pregnant women were...
View ArticlePrenatal fish oil supplementation associated with lower risk of asthma in...
1. Third trimester supplementation with long-chain polyunsaturated fatty acids (LCPUFA) reduces offspring risk of asthma or persistent wheeze and risk of lower respiratory tract infections (LRTI)....
View ArticleNo difference between placebo, amitriptyline and topiramate in reducing...
1. In this study, no significant intergroup differences between amitriptyline, topiramate and placebo for reduction in total number of headache days was observed. 2. Amitriptyline and topiramate were...
View ArticleBezlotoxumab associated with lower recurrence of C. difficile infection: The...
1. Bezlotoxumab therapy associated with significantly lower rate of recurrent C. difficile infection compared to placebo. 2. Actoxumab not efficacious when administered aloine or in combination with...
View ArticleResearchers validate scoring of postconcussive symptom measure to...
1. After analyzing multiple approaches to the Postconcussion Symptom Inventory (PCSI), researchers found that an increase in severity on 2 or more PCSI items by 1 point or more offered the highest...
View ArticleClinical prediction score predicts risk of neonatal rebound hyperbilirubinemia
1. A clinical prediction rule was developed to estimate the probability of rebound hyperbilirubinemia in newborns undergoing first-time inpatient phototherapy. 2. The strongest predictors of rebound...
View ArticleMost children needing end-of-life care receive it in acute care settings
1. In this retrospective study, the majority of children studied died of chronic conditions or congenital illnesses in institutional settings (intensive care unit [ICU], emergency department [ED], or...
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